Friday, January 29, 2016

Testosterone Deficiency Linked to Higher Mortality Rate, Still Undertreated


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A large body of research indicates that testosterone deficiency (aka hypogonadism or Low T) is associated with higher all-cause mortality among men and a significant reduction in the overall quality of their lives. Still, despite all this evidence, studies (1-2) show that only 10 to 12 percent of men suffering from testosterone deficiency receive treatment.

This discrepancy can be partially explained by a common misconception that testosterone replacement therapy (TRT) increases the risk of cardiovascular disease. The whole controversy was created by a few studies suggesting a negative impact of the hormone on heart health. Although these studies have been widely disproven, many people still have a lot of reservations about the procedure.

Most modern studies agree on the fact that testosterone therapy is safe and effective for men with hypogonadism. Moreover, research indicates that for testosterone deficient men, TRT leads to significant improvements in sexual function and bone density, while also helping gain lean muscle mass and lose fat (3-5).

Overall, testosterone replacement therapy provides a number of health benefits that are essential to improving the quality of life and longevity for men with low T. If you know that your testosterone levels are below normal, professionally administered TRT is likely to be your best treatment option.

References:
1. Hall SA, Araujo AB, Esche GR, Williams RE, Clark RV, Travison TG, et al. Treatment of symptomatic androgen deficiency: results from the Boston Area Community Health Survey. Arch Intern Med. 2008 May 26;168:1070-6.
2. Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006 Jul;60:762-9.
3. Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, et al. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol (Oxf). 2005 Sep;63:280-93.
4. Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren L. Onset of effects of testosterone treatment and time span until maximum effects are achieved. Eur J Endocrinol. 2011 Nov;165:675-85.
5. Corona G, Giagulli VA, Maseroli E, Vignozzi L, Aversa A, Zitzmann M, et al. THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study. Eur J Endocrinol. 2015 Nov 4.

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